USF1 and dyslipidemias: converging evidence for a functional intronic variant
نویسندگان
چکیده
منابع مشابه
USF1 and dyslipidemias: converging evidence for a functional intronic variant.
Upstream transcription factor 1 (USF1), the first gene associated with familial combined hyperlipidemia (FCHL), regulates numerous genes of glucose and lipid metabolism. Phenotypic overlap between FCHL, type 2 diabetes and the metabolic syndrome makes this gene an intriguing candidate in the disease process of these traits as well. As no disease-associated mutations in the coding region of USF1...
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BACKGROUND The upstream transcription factor 1 (USF1) gene is associated with familial combined hyperlipidemia, the most common genetic dyslipidemia in humans, as well as with various dyslipidemic changes in numerous other studies. Typical of complex disease-associated genes, neither the explicit mutations have been described nor the functional consequences for risk allele carriers been reporte...
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Update on evidence-based diagnosis and management of mixed dyslipidemias.
This article summarizes the principal publications and those evidence-based clinical trials on dyslipidemias, including their main findings and recommendations for practicing cardiologists and clinicians. Emphasis is given to the confirmed data regarding the pathophysiology as well as the diagnoses of dyslipidemias, and the established therapeutic approaches validated in multiple well supervise...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2005
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddi294